4-(1-Methylethyl)thiazole-5-carboxaldehyde

Base Information

Chemical Name:4-(1-Methylethyl)thiazole-5-carboxaldehyde
CAS No.:261710-80-9
Molecular Formula:C7H9 N O S
Molecular Weight:155.21746
Hs Code.:
DSSTox Substance ID:DTXSID601265316
Mol file:261710-80-9.mol

Synonyms:261710-80-9;4-(1-methylethyl)thiazole-5-carboxaldehyde;SCHEMBL6297883;CUMFTMHDINTVBT-UHFFFAOYSA-N;DTXSID601265316;4-iso-Propyl-thiazole-5-carbaldehyde;4-Isopropyl-1,3-thiazole-5-carbaldehyde;4-(1-Methylethyl)-5-thiazolecarboxaldehyde;5-Thiazolecarboxaldehyde,4-(1-methylethyl)-(9ci)

Suppliers and Price of 4-(1-Methylethyl)thiazole-5-carboxaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(1-Methylethyl)thiazole-5-carboxaldehyde

Chemical Property:

PSA：58.20000
LogP:2.07900
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:155.04048508
Heavy Atom Count:10
Complexity:127

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=C(SC=N1)C=O

Technology Process of 4-(1-Methylethyl)thiazole-5-carboxaldehyde

There total 2 articles about 4-(1-Methylethyl)thiazole-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 261710-81-0
5-(hydroxymethyl)-4-isopropyl-thiazole

: 261710-80-9
4-(1-methylethyl)thiazole-5-carboxaldehyde

Guidance literature:: With manganese(IV) oxide; In chloroform; at 20 ℃; for 2.5h;
DOI:10.1021/jm0003844

Reference yield:

: 81569-57-5
4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester

: 261710-80-9
4-(1-methylethyl)thiazole-5-carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL / toluene / 0 - 20 °C

2: MnO₂ / CHCl₃ / 2.5 h / 20 °C

With manganese(IV) oxide; diisobutylaluminium hydride; In chloroform; toluene;
DOI:10.1021/jm0003844

Reference yield:

: 261710-80-9
4-(1-methylethyl)thiazole-5-carboxaldehyde

: 3-(2-tert-Butyl-4-hydroxymethyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-isopropyl-6-[2-(4-isopropyl-thiazol-5-yl)-ethyl]-5,6-dihydro-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / acetonitrile; H₂O / 18 h / 20 °C

2.1: H₂ / 5percent Pd/BaSO₄ / tetrahydrofuran / 26 h / 1654.92 Torr

3.1: NaH / tetrahydrofuran / 0.33 h / 0 °C

3.2: n-BuLi / tetrahydrofuran / 0.5 h / 0 °C

3.3: tetrahydrofuran / 1.5 h / 0 - 20 °C

4.1: 1 N aq. NaOH / tetrahydrofuran / 1 h

4.2: aq. HCl / pH 4.5

5.1: K₂CO₃ / dimethylformamide / 20 °C

With sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; 5percent Pd/BaSO₄; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm0003844