81569-57-5

Basic information

• Product Name: 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester
• Synonyms: 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester
• CAS NO: 81569-57-5
• Molecular Weight: 199.274
• Mol File: 81569-57-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester(81569-57-5)
• EPA Substance Registry System: 4-(1-methylethyl)thiazole-5-carboxylic acid ethyl ester(81569-57-5)

Safety Data

• Hazardous Substances Data: 81569-57-5(Hazardous Substances Data)

Upstream product

• 115-08-2 thiocarboxamide 
• 35391-60-7 ethyl 2-chloro-4-methyl-3-oxopentanoate 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 81569-67-7 2-bromo-4-methyl-3-oxo-pentanoic acid ethyl ester 
• 72850-76-1 ethyl 2-amino-4-isopropyl-1,3-thiazole-5-carboxylate 

Downstream Products

• 72632-66-7 4-(propan-2-yl)-1,3-thiazol-5-amine 
• 261710-81-0 5-(hydroxymethyl)-4-isopropyl-thiazole 
• 261710-80-9 4-(1-methylethyl)thiazole-5-carboxaldehyde 
• 81569-42-8 4-isopropylthiazole-5-carboxylic acid 

Relevant articles and documents

Synthetic method of drug intermediate sulfur-containing nitrogen heterocyclic amine compound (by machine translation)

To the invention, 4 -N-BOC -3 - isopropylthiazole is obtained by reaction of 2 - methyl -4 - oxo-pentanoic acid ethyl ester, dichloromethane and sulfonyl chloride as a raw material, and then -3 - N-BOC - 2 - isopropylthiazole and HCl are added in the presence of ethanol as a solvent to obtain -4 - N-BOC-n-isopropythiazol -5 - methyl 4 -isoprop -5 -aminothiazole in the presence of triethylamine, and a NaOH solution is added as a solvent and then subjected to extraction washing to obtain 4 -yl -5 -aminothiazolethyl acetate in the presence of trifluoroethanol as a solvent and ethanol as a solvent to obtain ethyl acetate 4 - 5-propyl thiazole -5 - formic acid ethyl ester with ethanol as a 4 - solvent and an aqueous solution of N-BOC-5 n-isopropylthiazole 4 - and the like 4 -5 . The method has the advantages of clear steps, less waste, high yield, raw material saving and easy operation. (by machine translation)

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.