ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate

Base Information

• Chemical Name: ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate
• CAS No.: 743353-92-6
• Molecular Formula: C₂₃H₂₁N₃O₅S
• Molecular Weight: 451.503

Synonyms:ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate

Chemical Property of ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate

Chemical Property:

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Technology Process of ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate

There total 4 articles about ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 2-diazo-3-[(trimethylsilyl)oxy]but-3-enoate (94153-62-5) + (E)-1-(4-methoxyphenyl)-3-(4-methoxyphenylamino)-3-methylthioprop-2-ene-1-thione (743353-81-3) → ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate (743353-92-6)

Guidance literature:

With mercury(II) diacetate; In dichloromethane; at 20 ℃;

DOI:10.1021/jo049769a

Reference yield:

1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone (33868-76-7) → ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate (743353-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: BF₃*OEt₂ / toluene / 2 h / Heating

2: Lawesson's reagent / benzene / 0.5 h / Heating

3: 88 percent / Hg(OAc)2 / CH₂Cl₂ / 20 °C

With Lawessons reagent; boron trifluoride diethyl etherate; mercury(II) diacetate; In dichloromethane; toluene; benzene;

DOI:10.1021/jo049769a

Reference yield:

4-methoxy-aniline (104-94-9) → ethyl 2-diazo-3-{5-(4-methoxyphenyl)-3-(4-methoxyphenylamino)thiophen-2-yl}-3-oxopropanoate (743353-92-6)

Guidance literature:

Multi-step reaction with 3 steps

1: BF₃*OEt₂ / toluene / 2 h / Heating

2: Lawesson's reagent / benzene / 0.5 h / Heating

3: 88 percent / Hg(OAc)2 / CH₂Cl₂ / 20 °C

With Lawessons reagent; boron trifluoride diethyl etherate; mercury(II) diacetate; In dichloromethane; toluene; benzene;

DOI:10.1021/jo049769a

upstream raw materials:

ethyl 2-diazo-3-[(trimethylsilyl)oxy]but-3-enoate

(E)-1-(4-methoxyphenyl)-3-(4-methoxyphenylamino)-3-methylthioprop-2-ene-1-thione

1-(4-methoxyphenyl)-3,3-bis(methylsulfanyl)propenone

4-methoxy-aniline

Downstream raw materials:

6-diazo-2,4-di(4-methoxyphenyl)-4H-thieno[3,2-b]pyridine-5,7-dione

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