N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

Base Information

Chemical Name:N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide
CAS No.:1312711-58-2
Molecular Formula:C₂₈H₂₆F₅N₇O₂
Molecular Weight:587.552
Hs Code.:

Synonyms:N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

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Chemical Property of N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

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Technology Process of N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

There total 4 articles about N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 59-67-6
nicotinic acid

: 1312711-11-7
1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[4-(4-amino-2-(trifluoromethyl)phenyl)piperazin-1-yl]-propan-2-ol

: 1312711-58-2
N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2011.04.022

Reference yield:

: 381242-61-1
1-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

: 1312711-58-2
N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 5 h / 70 - 80 °C

2: hydrazine hydrate / ethanol / 3 h / 70 - 80 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.04.022

Reference yield:

: 777-37-7
4-chloro-3-(trifluoromethyl)nitrobenzene

: 1312711-58-2
N-(4-{4-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperazin-1-yl}-3-(trifluoromethyl)-phenyl)-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 10 h / Reflux

2: triethylamine / ethanol / 5 h / 70 - 80 °C

3: hydrazine hydrate / ethanol / 3 h / 70 - 80 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2011.04.022