5-hydroxy-8-methoxynaphthalene-1,4-dione

Base Information

• Chemical Name: 5-hydroxy-8-methoxynaphthalene-1,4-dione
• CAS No.: 21418-04-2
• Molecular Formula: C11H8 O4
• Molecular Weight: 204.1788
• Mol file: 21418-04-2.mol

Synonyms:1,4-Naphthoquinone,5-hydroxy-8-methoxy- (8CI); 8-Hydroxy-5-methoxy-1,4-naphthoquinone; NSC 339302

Chemical Property of 5-hydroxy-8-methoxynaphthalene-1,4-dione

Chemical Property:

• Vapor Pressure: 5.95E-09mmHg at 25°C
• Boiling Point: 456.5°Cat760mmHg
• Flash Point: 188.1°C
• Density: 1.408g/cm³

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-hydroxy-8-methoxynaphthalene-1,4-dione

There total 9 articles about 5-hydroxy-8-methoxynaphthalene-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4,8-Dimethoxy-1,5-naphthalindiol (129447-52-5) → 5-hydroxy-8-methoxy-1,4-naphthoquinone (21418-04-2)

Guidance literature:

With hydrogenchloride; iron(III) chloride; In methanol; acetonitrile; at 0 ℃; for 0.166667h;

DOI:10.1021/jo000684t

Reference yield: 47.0%

5,8-Dihydroxy-1,4-naphthoquinone (475-38-7) + methyl iodide (74-88-4) → 5,8-dimethoxynaphthoquinone (15013-16-8) + 5-hydroxy-8-methoxy-1,4-naphthoquinone (21418-04-2)

Guidance literature:

With silver(l) oxide; In chloroform; at 40 ℃; for 21h;

DOI:10.1021/jo00349a033

Reference yield:

5,8-Dihydroxy-1,4-naphthoquinone (475-38-7) + methyl iodide (74-88-4) → 5-hydroxy-8-methoxy-1,4-naphthoquinone (21418-04-2)

Guidance literature:

With silver(l) oxide; In dichloromethane; at 20 ℃; for 23h;

DOI:10.1021/cb400384c

upstream raw materials:

5,8-dimethoxynaphthoquinone

4,8-Dimethoxy-1,5-naphthalindiol

5,8-Dihydroxy-1,4-naphthoquinone

methyl iodide

Downstream raw materials:

Tetrangulol

Benzoic acid 5,8-dihydroxy-4-methoxy-naphthalen-1-yl ester

8-Hydroxy-5-methoxy-3-phenyl-3a,9a-dihydro-naphtho[2,3-d]isoxazole-4,9-dione

5-(benzoyloxy)-8-methoxy-1,4-naphthoquinone