2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide
• CAS No.: 35588-41-1
• Molecular Formula: C9H9 Cl2 N O2
• Molecular Weight: 234.082
• Hs Code.: 2924299090
• European Community (EC) Number: 659-617-4
• DSSTox Substance ID: DTXSID30354583
• Wikidata: Q82132815
• Mol file: 35588-41-1.mol

Synonyms:2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide;35588-41-1;MFCD00157382;SCHEMBL9468747;DTXSID30354583;STK300084;AKOS000266444;BS-10269;2,5'-DICHLORO-2'-METHOXYACETANILIDE;BB 0243225;CS-0307532;EN300-01685;2-Chloro-N-(5-chloro-2-methoxy-phenyl)-acet amide;Z56896294

Chemical Property of 2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.78E-05mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 363.7°C at 760 mmHg
• Flash Point: 173.7°C
• PSA: 38.33000
• Density: 1.378g/cm³
• LogP: 2.59890
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 233.0010339
• Heavy Atom Count: 14
• Complexity: 201

Purity/Quality:

98%Min ^*data from raw suppliers

2-Chloro-N-(5-chloro-2-methoxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)NC(=O)CCl

Technology Process of 2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide

There total 2 articles about 2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

chloroacetyl chloride (79-04-9) + 5-chloro-2-methoxyaniline (95-03-4) → 2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide (35588-41-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

→ 2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide (35588-41-1)

Guidance literature:

Cl-Acetylchlorid, entspr. Amin;

Reference yield: 79.0%

2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide (35588-41-1) + N-methylmorpholinium 3-cyano-5-{[4-(ethoxycarbonyl)phenyl]carbamoyl}-4-(2-furyl)-6-methyl-1,4-dihydropyridine-2-thiolate → C30H27ClN4O6S

Guidance literature:

N-methylmorpholinium 3-cyano-5-{[4-(ethoxycarbonyl)phenyl]carbamoyl}-4-(2-furyl)-6-methyl-1,4-dihydropyridine-2-thiolate; With potassium hydroxide; In ethanol; water; Heating;

2-chloro-N-(5-chloro-2-methoxyphenyl)acetamide; In ethanol; water; at 40 - 50 ℃;

DOI:10.1134/S1070363221120306

upstream raw materials:

chloroacetyl chloride

5-chloro-2-methoxyaniline

Downstream raw materials:

6-chloro-2H-1,4-benzoxazin-3(4H)-one

N,N-diethyl-glycine-(5-chloro-2-methoxy-anilide); hydrochloride

N-(5-Chloro-2-methoxyphenyl)-4-[2-[3-cyano-7-[3-(trifluoromethyl)phenyl]pyrazolo[1.5-a]pyrimidin-4(5H)-yl]-2-oxoethyl]-1-piperazineacetamide

C₁₈H₁₆Cl₂N₂O₄

Refernces

• 1、 -. "Nicotinic acid or isonicotinic acid compound and application thereof". Paragraph 0066. . Retrieved 2017/08/25.
• 2、 -. "BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS". Page/Page column 179-180. . Retrieved 2010/11/28.