(S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

Base Information

Chemical Name:(S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol
CAS No.:1416443-79-2
Molecular Formula:C₁₆H₁₇ClO₄
Molecular Weight:308.762
Hs Code.:

Synonyms:(S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

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Chemical Property of (S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

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Technology Process of (S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

There total 5 articles about (S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1416443-77-0
(R)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol acetonide

: 1416443-79-2
(S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

Guidance literature:: With hydrogenchloride; In ethanol; water; at 75 ℃; for 4h;
DOI:10.1016/j.ejmech.2012.09.049

Reference yield:

: 4525-75-1
2-chlorophenyl acetate

: 1416443-79-2
(S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / 1,2-dichloro-benzene / 5 h / 20 - 100 °C

2: tetrabutylammomium bromide; sodium hydroxide / water / 5 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 168 h / 0 - 20 °C

4: water; sodium hydroxide / methanol / 2 h

5: potassium carbonate / N,N-dimethyl-formamide / 4 h

6: hydrogenchloride / ethanol; water / 4 h / 75 °C

With hydrogenchloride; aluminum (III) chloride; tetrabutylammomium bromide; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene; 1: |Fries Phenol Ester Rearrangement / 3: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1016/j.ejmech.2012.09.049

Reference yield:

: 56207-40-0
2-benzyloxy-3-chlorophenol

: 1416443-79-2
(S)-3-(2-benzyloxy-3-chlorophenoxy)-1,2-propanediol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h

2: hydrogenchloride / ethanol; water / 4 h / 75 °C

With hydrogenchloride; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.09.049