Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

Base Information

Chemical Name:Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester
CAS No.:96685-54-0
Molecular Formula:C₄₁H₆₆O₅SSi
Molecular Weight:699.124
Hs Code.:

Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

Synonyms:Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

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Chemical Property of Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

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Technology Process of Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

There total 21 articles about Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96843-37-7,96894-96-1
C₂₅H₃₆O₄S

: 96685-54-0
Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 72 percent / HCl, H₂ / 5percent Pd/C / methanol / 5 h / Ambient temperature

2: 98 percent / p-toluenesulfonic acid / 10 h / Heating

3: 1.) O₃, 2.) LiOH / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) THF, RT, 2 h

4: 73 percent / camphorsulfonic acid / benzene / 2 h / Heating

5: 72 percent / LiAlH₄ / tetrahydrofuran / 9 h / Ambient temperature

6: 93 percent / 4-(dimethylamino)pyridine, pyridine / 5 h / Ambient temperature

7: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

8: 95 percent / HCl / acetone / 6 h / Ambient temperature

9: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, 0 deg C, 30 min

10: 50 percent / LDA / tetrahydrofuran / 0.17 h / -78 °C

11: pyridine / 1 h / 0 °C

12: 1.) LiBr, Li₂CO₃, DMF, 2.) H₂ / 2.) 5percent Pd/C / 1.) 150 deg C, 4 h, 2.) ethyl acetate, RT, 8 h

With pyridine; hydrogenchloride; dmap; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; camphor-10-sulfonic acid; hydrogen; lithium carbonate; toluene-4-sulfonic acid; ozone; N,N-dimethyl-formamide; lithium bromide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; acetone; benzene;
DOI:10.1021/jo00376a049

Reference yield:

: 96685-46-0
(-)-<1(S)-methyl-2(S)-((phenylsylfonyl)methyl)-5(R)-(1(R),5-dimethylhexyl)cyclopentyl>acetaldehyde

: 96685-54-0
Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, 0 deg C, 30 min

2: 50 percent / LDA / tetrahydrofuran / 0.17 h / -78 °C

3: pyridine / 1 h / 0 °C

4: 1.) LiBr, Li₂CO₃, DMF, 2.) H₂ / 2.) 5percent Pd/C / 1.) 150 deg C, 4 h, 2.) ethyl acetate, RT, 8 h

With pyridine; n-butyllithium; hydrogen; lithium carbonate; N,N-dimethyl-formamide; lithium bromide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jo00376a049

Reference yield:

: 96843-38-8
(-)-(1S,3aR,4R,7aS)-1-<(phenylsulfonyl)methyl>-4-(4-methylpentyl)-3a,4,5,6,7,7a-hexahydro-7a-methylindan-5-one

: 96685-54-0
Acetic acid 1-[(1R,3aR,7aR)-4-benzenesulfonyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yl]-2-[5-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-ethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 98 percent / p-toluenesulfonic acid / 10 h / Heating

2: 1.) O₃, 2.) LiOH / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) THF, RT, 2 h

3: 73 percent / camphorsulfonic acid / benzene / 2 h / Heating

4: 72 percent / LiAlH₄ / tetrahydrofuran / 9 h / Ambient temperature

5: 93 percent / 4-(dimethylamino)pyridine, pyridine / 5 h / Ambient temperature

6: 95 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

7: 95 percent / HCl / acetone / 6 h / Ambient temperature

8: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, 0 deg C, 30 min

9: 50 percent / LDA / tetrahydrofuran / 0.17 h / -78 °C

10: pyridine / 1 h / 0 °C

11: 1.) LiBr, Li₂CO₃, DMF, 2.) H₂ / 2.) 5percent Pd/C / 1.) 150 deg C, 4 h, 2.) ethyl acetate, RT, 8 h

With pyridine; hydrogenchloride; dmap; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; camphor-10-sulfonic acid; hydrogen; lithium carbonate; toluene-4-sulfonic acid; ozone; N,N-dimethyl-formamide; lithium bromide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; acetone; benzene;
DOI:10.1021/jo00376a049