ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

Base Information

Chemical Name:ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate
CAS No.:1414931-71-7
Molecular Formula:C₃₂H₃₀Cl₂N₂O₃
Molecular Weight:561.508
Hs Code.:

Synonyms:ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

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Chemical Property of ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

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Technology Process of ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

There total 5 articles about ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1414931-82-0
5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxylic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 1414931-71-7
ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 825-40-1
2-bromo-p-chloroacetophenone

: 1414931-71-7
ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C

2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 90 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With methanol; sodium tetrahydroborate; water; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1086601-87-7
1-(2-bromo-4-chlorophenyl)ethanol

: 1414931-71-7
ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 90 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With water; potassium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;