N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide

Base Information

• Chemical Name: N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide
• CAS No.: 811430-93-0
• Molecular Formula: C₂₃H₂₇NO₃SSi
• Molecular Weight: 425.624
• Mol file: 811430-93-0.mol

Synonyms:N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide

Chemical Property of N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide

There total 2 articles about N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + 4-methyl-N-prop-2-ynyl-N-(3-trimethylsilylprop-2-ynyl)benzenesulfonamide (170751-30-1) → N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide (811430-93-0)

Guidance literature:

4-methyl-N-prop-2-ynyl-N-(3-trimethylsilylprop-2-ynyl)benzenesulfonamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

benzaldehyde; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/ol048351w

Reference yield:

4-methyl-N,N-diprop-2-ynylbenzenesulfonamide (18773-54-1) → N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide (811430-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: LHMDS / tetrahydrofuran / 0.33 h / -78 °C

2: LHMDS / tetrahydrofuran / -78 - 20 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/jo070513p

Reference yield: 100.0%

tert-butylsulfinyl chloride (31562-43-3) + N-(4-hydroxy-4-phenyl-but-2-ynyl)-4-methyl-N-(3-trimethylsilanyl-prop-2-ynyl)-benzenesulfonamide (811430-93-0) → C27H35NO3S2Si

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jo070513p

upstream raw materials:

benzaldehyde

4-methyl-N-prop-2-ynyl-N-(3-trimethylsilylprop-2-ynyl)benzenesulfonamide

4-methyl-N,N-diprop-2-ynylbenzenesulfonamide

Downstream raw materials:

N-[4-phenyl-2-(phenylsulfonyl)-2,3-butadienyl]-N-[3-(trimethylsilyl)-2-propynyl]-(4-methylbenzene)sulfonamide

N-{4-phenyl-2-[(2,4,6-trimethylbenzene)sulfonyl]-2,3-butadienyl}-N-[3-(trimethylsilyl)-2-propynyl]-4-(methylbenzene)sulfonamide

N-[4-phenyl-2-(2-methylpropyl-2-sulfonyl)-2,3-butadienyl]-N-[3-(trimethylsilyl)-2-propynyl]-(4-methylbenzene)sulfonamide