(Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

Base Information

Chemical Name:(Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate
CAS No.:1538580-44-7
Molecular Formula:C₂₄H₂₅FO₃S
Molecular Weight:412.525
Hs Code.:

Synonyms:(Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

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Technology Process of (Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

There total 3 articles about (Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1538580-40-3
(Z)-4-((tert-butyldimethylsilyl)oxy)butyl 5-fluoro-2-methyl-1-(4-(methylthio)-benzylidene)-1H-inden-3-ylacetate

: 1538580-44-7
(Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

Guidance literature:: With camphor-10-sulfonic acid; In methanol; dichloromethane; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.014

Reference yield:

: 38194-50-2
Sulindac

: 1538580-44-7
(Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride; zinc / dichloromethane; tetrahydrofuran / 2.5 h / Cooling with acetone-dry ice; Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: camphor-10-sulfonic acid / dichloromethane; methanol / 3 h / Inert atmosphere

With dmap; camphor-10-sulfonic acid; titanium tetrachloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2013.12.014

Reference yield:

: 49627-27-2
sulindac sulfide

: 1538580-44-7
(Z)-4-hydroxybutyl 5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-ylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 4 h / 20 °C / Inert atmosphere

2: camphor-10-sulfonic acid / dichloromethane; methanol / 3 h / Inert atmosphere

With dmap; camphor-10-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2013.12.014