(2-<2H1>)-4-methoxyphenylethyne

Base Information

• Chemical Name: (2-<2H1>)-4-methoxyphenylethyne
• CAS No.: 54159-16-9
• Molecular Formula: C₉H₈O
• Molecular Weight: 133.154
• Mol file: 54159-16-9.mol

Synonyms:(2-<2H1>)-4-methoxyphenylethyne

Chemical Property of (2-<2H1>)-4-methoxyphenylethyne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-<2H1>)-4-methoxyphenylethyne

There total 4 articles about (2-<2H1>)-4-methoxyphenylethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxyphenylacetylen (768-60-5) → (2-<2H1>)-4-methoxyphenylethyne (54159-16-9)

Guidance literature:

With n-butyllithium; water-d2; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1021/jo005530s

Reference yield: 70.0%

1-(2,2-dibromovinyl)-4-methoxybenzene-1-d1 → (2-<2H1>)-4-methoxyphenylethyne (54159-16-9)

Guidance literature:

With n-butyllithium; In hexane; at -78 - 20 ℃; for 4h;

DOI:10.1002/ejoc.200601137

Reference yield: 20.0%

O-deuterio-2-oxo-acetic acid + 4-methoxyphenylacetylen (768-60-5) → (2-<2H1>)-4-methoxyphenylethyne (54159-16-9) + C10H7(2)H3O2

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; 1,3-bis-(diphenylphosphino)propane; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Reagent/catalyst; stereoselective reaction; Schlenk technique;

DOI:10.1039/c7cc09629a

upstream raw materials:

4-methoxyphenylacetylen

Downstream raw materials:

1-methoxy-4-(4,4,4-trifluorobut-1-yn-1-yl)benzene

C₁₁H₈⁽²⁾HF₃O