2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Base Information

Chemical Name:2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine
CAS No.:1263868-34-3
Molecular Formula:C₁₆H₁₅Cl₂N₃
Molecular Weight:320.221
Hs Code.:

Synonyms:2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

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Chemical Property of 2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

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Technology Process of 2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

There total 9 articles about 2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263868-24-1
2,4-dichloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

: 3-chloroazetidine hydrochloride

: 1263868-34-3
2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3h;

Reference yield:

: 120-92-3
cyclopentanone

: 1263868-34-3
2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 2.5 h / 0 °C / Reflux

1.2: Cooling with ice

2.1: formic acid; dihydrogen peroxide / 4 h / 20 °C

3.1: 1.75 h / 58 - 130 °C

4.1: ammonia / water / 5 h / Heating

5.1: trichlorophosphate / 1 h / 110 °C / Microwave irradiation

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

With formic acid; ammonia; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether; water;

Reference yield:

: 1198-34-1
2-Phenylcyclopentanone

: 1263868-34-3
2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.75 h / 58 - 130 °C

2: ammonia / water / 5 h / Heating

3: trichlorophosphate / 1 h / 110 °C / Microwave irradiation

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 20 °C

With ammonia; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; water;