3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

Base Information

Chemical Name:3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one
CAS No.:161659-96-7
Molecular Formula:C₃₂H₄₆N₂O₇Si
Molecular Weight:598.812
Hs Code.:

3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

Synonyms:3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

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Chemical Property of 3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

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Technology Process of 3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

There total 1 articles about 3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 40630-84-0
allyl bromoacetate

: 158299-15-1
3-<(2R)-2-<(2R,3S)-3-<(1R)-1-(tert-Butyldimethylsiloxy)ethyl>-4-oxoazetidin-2-yl>propionyl>spiro-<2,3-dihydro-4H-1,3-benzoxazine-2,1'-cyclohexan>-4-one

: 161659-96-7
3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -50 - -45 ℃;
DOI:10.1021/jo00110a001

Reference yield: 94.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 161659-96-7
3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

: 153471-17-1
(4R,5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(diphenoxy-phosphoryloxy)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester

Guidance literature:: 3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one; With chloro-trimethyl-silane; sodium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 0.25h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; at -10 - 0 ℃; for 2h; Temperature;

Reference yield: 82.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 161659-96-7
3-<(2R)-2-<(3S,4R)-1-<(allyloxycarbonyl)methyl>-3-<(1R)-1-(tert-butyldimethylsilyloxy)ethyl>-2-oxoazetidin-4-yl>propionyl>spiro<2H-1,3-benzoxazine-2,1'-cyclohexan>-4(3H)-one

: (4R,5S,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-(diphenoxy-phosphoryl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester

Guidance literature:: With chloro-trimethyl-silane; sodium hexamethyldisilazane; In tetrahydrofuran; 1.) -35 to -25 deg C, 2.) 0 deg C;
DOI:10.1021/jo00110a001