5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole
CAS No.:1567335-24-3
Molecular Formula:C₂₄H₂₇ClN₂O₂
Molecular Weight:410.944
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

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Chemical Property of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

Chemical Property:

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Technology Process of 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

There total 6 articles about 5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1567335-23-2
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyl-2,5-dihydrofuran-3-yl)-1H-pyrazole

: 1567335-24-3
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

Guidance literature:: With platinum(IV) oxide; hydrogen; In ethyl acetate;

Reference yield:

: 79984-63-7
N'-(2-methoxyphenyl)acetohydrazide

: 1567335-24-3
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: phosphorus trichloride / 1,2-dichloro-ethane / 2 h / 50 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 1 h / 70 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

4: platinum(IV) oxide; hydrogen / ethyl acetate

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 5455-94-7
2,2,5,5-tetramethyltetrahydro-3-oxofuran

: 1567335-24-3
5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,5,5-tetramethyltetrahydrofuran-3-yl)-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethyl acetate

With platinum(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium acetate; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; toluene;