Cyclopropanecarboxylic acid, 2-formyl-, methyl ester, (1R,2R)-rel- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-formyl-, methyl ester, (1R,2R)-rel- (9CI)
• CAS No.: 35501-84-9
• Molecular Formula: C₆H₈O₃
• Molecular Weight: 128.128
• Mol file: 35501-84-9.mol

Synonyms:Cyclopropanecarboxylicacid, 2-formyl-, methyl ester, trans-

Chemical Property of Cyclopropanecarboxylic acid, 2-formyl-, methyl ester, (1R,2R)-rel- (9CI)

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-formyl-, methyl ester, (1R,2R)-rel- (9CI)

There total 34 articles about Cyclopropanecarboxylic acid, 2-formyl-, methyl ester, (1R,2R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(±)-methyl-2-(hydroxymethyl)cyclopropanecarboxylate → cis-2-formil-1-ciclopropanocarboxilato de metilo (35501-84-9)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃;

DOI:10.1016/S0960-894X(02)00793-X

Reference yield: 96.0%

methyl (±)-trans-2-(hydroxymethyl)cyclopropanecarboxylate (13482-81-0,31443-73-9,35501-83-8,110115-17-8) → methyl trans-2-formylcyclopropane carboxylate (35501-84-9)

Guidance literature:

With oxalyl dichloride; triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 - -70 ℃; for 1h; Inert atmosphere;

DOI:10.3762/bjoc.10.302

Reference yield: 96.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 4-hidroxi-3-oxabiciclo<3.1.0>hexan-2-ona → cis-2-formil-1-ciclopropanocarboxilato de metilo (35501-84-9)

Guidance literature:

In diethyl ether; ethyl acetate; at -10 ℃; for 1h;

upstream raw materials:

(+/-)-trans-2-Carbomethoxycyclopropanecarbonyl-chloride

racemic trans-2-methoxycarbonylcyclopropanecarboxylic acid

dimethyl trans-1,2-cyclopropanedicarboxylate

methyl-4-bromo-2-butenoate

Downstream raw materials:

(1R,2S)-2-(3H-Imidazol-4-yl)-cyclopropanecarboxylic acid