1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER

Base Information

• Chemical Name: 1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER
• CAS No.: 13279-88-4
• Molecular Formula: C6H8 O4
• Molecular Weight: 158.1519
• Hs Code.: 2918990090
• Mol file: 13279-88-4.mol

Synonyms:1,2-Cyclopropanedicarboxylicacid, monomethyl ester (8CI,9CI); 2-(Methoxycarbonyl)-1-cyclopropanecarboxylicacid

Chemical Property of 1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER

Chemical Property:

• Melting Point: 46-47 °C
• Boiling Point: 253.9±33.0 °C(Predicted)
• PKA: 4.10±0.11(Predicted)
• PSA: 63.60000
• Density: 1.397±0.06 g/cm3(Predicted)
• LogP: 0.41430
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-(Methoxycarbonyl)cyclopropanecarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER

There total 11 articles about 1,1-CYCLOPROPANEDICARBOXYLIC ACID MONOETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dimethyl cis-cyclopropane-1,2-dicarboxylate (826-34-6) → (±)-2-(methoxycarbonyl)cyclopropanecarboxylic acid (13279-88-4,31420-47-0,52920-02-2,88335-86-8,88335-87-9,88335-96-0,88335-97-1,134625-74-4)

Guidance literature:

dimethyl cis-cyclopropane-1,2-dicarboxylate; With sodium hydroxide; In methanol; water; at 20 ℃;

With hydrogenchloride; In water;

Reference yield: 86.0%

dimethyl cis-cyclopropane-1,2-dicarboxylate (826-34-6) → cis-1,2-cyclopropanedicarboxylic acid (696-74-2,696-75-3) + (±)-2-(methoxycarbonyl)cyclopropanecarboxylic acid (13279-88-4,31420-47-0,52920-02-2,88335-86-8,88335-87-9,88335-96-0,88335-97-1,134625-74-4)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Heating;

DOI:10.1016/0040-4020(95)00367-H

Reference yield: 84.0%

dimethyl trans-1,2-cyclopropanedicarboxylate (826-35-7) → racemic trans-2-methoxycarbonylcyclopropanecarboxylic acid (13279-88-4,31420-47-0,52920-02-2,88335-86-8,88335-87-9,88335-96-0,88335-97-1,134625-74-4)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; for 1h; Inert atmosphere;

DOI:10.3762/bjoc.10.302

upstream raw materials:

cis-1,2-cyclopropanedicarboxylic acid anhydride

sodium methylate

dimethyl cis-cyclopropane-1,2-dicarboxylate

methanol

Downstream raw materials:

(+/-)-trans-2-Carbomethoxycyclopropanecarbonyl-chloride

methyl 2-({[6-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-4-methylphenoxy)imidazo[1,2-b]pyridazin-2-yl]amino}carbonyl)cyclopropanecarboxylate