2,4-dichloro-N-phenethylbenzamide

Base Information

• Chemical Name: 2,4-dichloro-N-phenethylbenzamide
• CAS No.: 157729-55-0
• Molecular Formula: C₁₅H₁₃Cl₂NO
• Molecular Weight: 294.18
• European Community (EC) Number: 653-891-9
• Nikkaji Number: J3.150.124E
• Mol file: 157729-55-0.mol

Synonyms:2,4-dichloro-N-phenethylbenzamide;2,4-dichloro-N-(2-phenylethyl)benzamide;Oprea1_485120;STL356770;AKOS000439760;AN-652/41130061

Chemical Property of 2,4-dichloro-N-phenethylbenzamide

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 293.0374194
• Heavy Atom Count: 19
• Complexity: 292

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCNC(=O)C2=C(C=C(C=C2)Cl)Cl

Technology Process of 2,4-dichloro-N-phenethylbenzamide

There total 2 articles about 2,4-dichloro-N-phenethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2,4-dichlorobenzaldeyhde (874-42-0) + phenethylamine (64-04-0) → 2,4-dichloro-N-phenethylbenzamide (157729-55-0)

Guidance literature:

With tert.-butylhydroperoxide; zinc dibromide; In water; at 80 ℃; for 16h;

DOI:10.1016/j.tetlet.2012.12.010

Reference yield:

phenethylamine (64-04-0) + 2,4-dichlorobenzoyl chloride (89-75-8) → 2,4-dichloro-N-phenethylbenzamide (157729-55-0)

Guidance literature:

With potassium hydroxide;

DOI:10.1007/s00706-015-1471-2

Reference yield:

2,4-dichloro-N-phenethylbenzamide (157729-55-0) → C23H17Cl3N4O4S2

Guidance literature:

Multi-step reaction with 4 steps

1.1: chlorosulfonic acid / chloroform

2.1: ammonium hydroxide

3.1: potassium carbonate / acetone / 0.25 h / Reflux

3.2: 192 h / Reflux

4.1: toluene / 240 h / Reflux

With chlorosulfonic acid; ammonium hydroxide; potassium carbonate; In chloroform; acetone; toluene;

DOI:10.1007/s00706-015-1471-2

upstream raw materials:

2,4-dichlorobenzaldeyhde

phenethylamine

2,4-dichlorobenzoyl chloride