(E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide

Base Information

• Chemical Name: (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide
• CAS No.: 1344674-73-2
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.364
• Mol file: 1344674-73-2.mol

Synonyms:(E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide

Chemical Property of (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide

There total 3 articles about (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(α-aminoacetyl)toluene (69872-37-3) + (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) → (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide (1344674-73-2)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; at -15 - 20 ℃;

DOI:10.1016/j.bmcl.2011.08.099

Reference yield:

4-(bromoacetyl)toluene (619-41-0) → (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide (1344674-73-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / methanol; water / 0 - 20 °C

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 5 h / 20 °C / 1810.07 - 2068.65 Torr

3: diisopropyl-carbodiimide / dichloromethane / -15 - 20 °C

With hydrogenchloride; sodium azide; palladium 10% on activated carbon; hydrogen; diisopropyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.08.099

Reference yield:

2-azido-1-(4-methylphenyl)ethan-1-one (6595-30-8) → (E)-3-(4-hydroxy-3-methoxyphenyl)-N-(2-oxo-2-p-tolylethyl)acrylamide (1344674-73-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 5 h / 20 °C / 1810.07 - 2068.65 Torr

2: diisopropyl-carbodiimide / dichloromethane / -15 - 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; diisopropyl-carbodiimide; In methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.08.099

upstream raw materials:

4-(α-aminoacetyl)toluene

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

2-azido-1-(4-methylphenyl)ethan-1-one

4-(bromoacetyl)toluene

Downstream raw materials:

(E)-N-(2-hydroxy-2-p-tolylethyl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide