2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

Base Information

Chemical Name:2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole
CAS No.:784144-78-1
Molecular Formula:C₁₈H₁₂F₃NO₂
Molecular Weight:331.294
Hs Code.:

Synonyms:2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

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Chemical Property of 2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

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Technology Process of 2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

There total 3 articles about 2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 784144-74-7
2-(4-hydroxy-2-trifluoromethyl-4H-chromen-4-yl)-1-phenylethan-1-one oxime

: 784144-78-1
2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

Guidance literature:: With hydrogenchloride; In ethanol;
DOI:10.1007/s11172-006-0288-x

Reference yield:

: 10341-75-0
(E)-1-phenylethanone oxime

: 784144-78-1
2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / diethyl ether / 0.67 h

1.2: 72 percent / diethyl ether; tetrahydrofuran / 2 h / 20 °C

2.1: 83 percent / HCl / ethanol

With hydrogenchloride; lithium diisopropyl amide; In diethyl ether; ethanol;
DOI:10.1007/s11172-006-0288-x

Reference yield:

: 151668-40-5
2-trifluoromethyl-4-chromone

: 784144-78-1
2-(trifluoromethyl)-4H-chromene-4-spiro-5'-3'-phenyl-4',5'-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / diethyl ether / 0.67 h

1.2: 72 percent / diethyl ether; tetrahydrofuran / 2 h / 20 °C

2.1: 83 percent / HCl / ethanol

With hydrogenchloride; lithium diisopropyl amide; In diethyl ether; ethanol;
DOI:10.1007/s11172-006-0288-x