(4aR^*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline

Base Information

• Chemical Name: (4aR^*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline
• CAS No.: 132646-75-4
• Molecular Formula: C₁₈H₂₅NO₄S
• Molecular Weight: 351.467

Synonyms:(4aR^*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline

Chemical Property of (4aR^*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline

Chemical Property:

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Technology Process of (4aR^*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline

There total 3 articles about (4aR^*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1,1-dimethoxyethylene (922-69-0) + 1-(1-cyclohexenyl)-1-<(phenylsulfonyl)imino>ethane (118922-09-1) → (4aR*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline (132646-75-4)

Guidance literature:

In dichloromethane; at 25 ℃; for 96h; under 9000720 Torr;

Reference yield:

benzenesulphinyl chloride (4972-29-6) → (4aR*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline (132646-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Et₃N / CCl₄ / 1.) 0 deg C, 15 min, 2.) 25 deg C, 12 h

2: 63 percent / CH₂Cl₂ / 96 h / 25 °C / 9000720 Torr

With triethylamine; In tetrachloromethane; dichloromethane;

Reference yield:

(E)-1-(cyclohex-1-en-1-yl)ethan-1-one oxime (67267-61-2) → (4aR*)-3,3-dimethoxy-1-methyl-2-(phenylsulfonyl)-2,3,4,4a,5,6,7,8-octahydroisoquinoline (132646-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / Et₃N / CCl₄ / 1.) 0 deg C, 15 min, 2.) 25 deg C, 12 h

2: 63 percent / CH₂Cl₂ / 96 h / 25 °C / 9000720 Torr

With triethylamine; In tetrachloromethane; dichloromethane;

upstream raw materials:

1,1-dimethoxyethylene

1-(1-cyclohexenyl)-1-<(phenylsulfonyl)imino>ethane

benzenesulphinyl chloride

(E)-1-(cyclohex-1-en-1-yl)ethan-1-one oxime

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