922-69-0

Basic information

• Product Name: 1,1-DIMETHOXYETHENE
• Synonyms: KETENE DIMETHYL ACETAL;1,1-DIMETHOXYETHENE;1,1-DIMETHOXYETHYLENE
• CAS NO: 922-69-0
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.11
• Mol File: 922-69-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 93-94 °C
• Boiling Point: 89 °C
• Flash Point: 6 °C
• Appearance: /
• Density: 0.93 g/mL at 20 °C
• Vapor Pressure: 342mmHg at 25°C
• Refractive Index: 1.379
• CAS DataBase Reference: 1,1-DIMETHOXYETHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIMETHOXYETHENE(922-69-0)
• EPA Substance Registry System: 1,1-DIMETHOXYETHENE(922-69-0)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26
• RIDADR: UN 1993 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 922-69-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H8O2/c1-4(5-2)6-3/h1H2,2-3H3

Upstream product

• 97-97-2 chloroacetaldehyde dimethyl acetal 
• 1445-45-0 Trimethyl orthoacetate 
• 40070-40-4 trimethyl 2-bromoorthoacetate 
• 71-43-2 benzene 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 598-56-1 N,N-dimethyl-ethanamine 
• 23012-06-8 1,1-dimethoxy-ethylium 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 142-84-7 di-n-propylamine 

Downstream Products

• 67-56-1 methanol 
• 534-15-6 1,1-dimethoxyethane 
• 131543-46-9 Glyoxal 
• 79-20-9 acetic acid methyl ester 
• 1228-98-4 4,4-dimethoxy-1,1-diphenyl-but-3-en-2-one 
• 1445-45-0 Trimethyl orthoacetate 
• 123-73-9 trans-Crotonaldehyde 
• 623-43-8 crotonic acid methyl ester 
• 20473-61-4 4-methoxy-2-phenyl-1,3-oxazole 
• 20503-54-2 4,4-dimethoxy-2-phenyl-4,5-dihydro-oxazole 
• 51788-44-4 6,6-dimethoxy-2,2-dimethyl-1,3-diphenyl-2-sila-bicyclo[3.2.0]hept-3-ene 
• 88905-22-0 7,7-Dimethoxy-3-methyl-1-p-tolyl-3-aza-bicyclo[3.2.0]heptane-2,4-dione 
• 116015-72-6 4,6-O-methoxyethylidenesucrose 
• 1008-73-7 4-phenyldihydrofuran-2(3H)-one 

Relevant articles and documents

Preparation method of 2-fluorous methyl acrylate

The invention discloses a preparation method of 2-fluorous methyl acrylate. The preparation method comprises the following steps: (1) pyrolyzing trimethyl orthoacetate at 150 to 300 DEG C to obtain 1,1-dimethoxy ethane; (2) enabling reaction between 1,1-dimethoxy ethane and dichlorofluoromethane to obtain 1-chloride-1-fluorine-2,2-dimethoxy cyclopropane; (3) pyrolyzing the 1-chloride-1-fluorine-2,2-dimethoxy cyclopropane to obtain 2-fluorous methyl acrylate shown as the formula I.

Synthesis of mimosamycin

Mimosamycin (1) was synthesized in eight steps with an overall yield of 13% from 2-methoxy-3-methyl-1,4-benzoquinone by regioselective introduction of a chloromethyl group at C-6 and a methoxycarbonylmethyl group at C-5 and subsequent reaction of the intermediate methyl (o- (chloromethyl)phenyl)acetate derivative 16 with methylamine. Oxidation of the 5,7,8-trimethoxy-2,6-dimethyl-1,4-dihydroisoquinoline-3(2H)-one 17 thus obtained, using cerium(IV) ammonium nitrate as a selective oxidizing agent, gave mimosamycin (1) in good overall yield.