Technology Process of 5-azido-2-chlorobenzyl alcohol
There total 3 articles about 5-azido-2-chlorobenzyl alcohol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-chloro-5-hydroxymethyl aniline;
With
sulfuric acid; sodium nitrite;
In
water;
for 0.5h;
cooling;
With
sodium azide;
In
water;
at 20 ℃;
for 16h;
DOI:10.1016/j.tet.2006.04.056
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 72 percent / Fe; AcOH / ethanol / 4 h / Heating
2.1: sodium nitrite; sulfuric acid / H2O / 0.5 h / cooling
2.2: 57 percent / sodium azide / H2O / 16 h / 20 °C
With
sulfuric acid; iron; acetic acid; sodium nitrite;
In
ethanol; water;
DOI:10.1016/j.tet.2006.04.056
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 94 percent / NaBH4 / methanol / 24 h / 0 - 25 °C
2.1: 72 percent / Fe; AcOH / ethanol / 4 h / Heating
3.1: sodium nitrite; sulfuric acid / H2O / 0.5 h / cooling
3.2: 57 percent / sodium azide / H2O / 16 h / 20 °C
With
sodium tetrahydroborate; sulfuric acid; iron; acetic acid; sodium nitrite;
In
methanol; ethanol; water;
DOI:10.1016/j.tet.2006.04.056
