3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine

Base Information

• Chemical Name: 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine
• CAS No.: 902135-44-8
• Molecular Formula: C₃₃H₃₇N₃O₂
• Molecular Weight: 507.676
• Mol file: 902135-44-8.mol

Synonyms:3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine

Chemical Property of 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine

There total 4 articles about 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

3-benzyl-5-(4-benzyloxy)phenyl-6-methylpyrazin-2-amine (902135-43-7) + n-octanoic acid chloride (111-64-8) → 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine (902135-44-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1016/j.tet.2006.04.044

Reference yield:

3-benzyl-5-bromo-6-methylpyrazin-2-amine (902135-42-6) → 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine (902135-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Na₂CO₃ / Pd(PPh₃)4 / dioxane; H₂O / 2 h / 110 °C

2: 52 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With pyridine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; 1: Suzuki coupling;

DOI:10.1016/j.tet.2006.04.044

Reference yield:

6-methylpyrazin-2-amine (5521-56-2) → 3-benzyl-5-(4-benzyloxy)phenyl-6-methyl-2-(octanamido)pyrazine (902135-44-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 46 percent / pyridine; tetra-n-butylammonium tribromide / CHCl₃ / 2 h / Heating

2.1: PdCl₂(PPh₃)2 / dimethylformamide / 2.5 h / 130 °C

2.2: 36 percent / KF / methanol / 1 h / 20 °C

3.1: 94 percent / Na₂CO₃ / Pd(PPh₃)4 / dioxane; H₂O / 2 h / 110 °C

4.1: 52 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With pyridine; tetra-N-butylammonium tribromide; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 2.1: Stille coupling / 3.1: Suzuki coupling;

DOI:10.1016/j.tet.2006.04.044

upstream raw materials:

3-benzyl-5-(4-benzyloxy)phenyl-6-methylpyrazin-2-amine

n-octanoic acid chloride

3-benzyl-5-bromo-6-methylpyrazin-2-amine

6-methylpyrazin-2-amine