(E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:(E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline
CAS No.:1379771-20-6
Molecular Formula:C₂₅H₂₂F₃NO₃S
Molecular Weight:473.516
Hs Code.:

Synonyms:(E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

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Chemical Property of (E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

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Technology Process of (E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

There total 2 articles about (E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 455-13-0
4-Iodobenzotrifluoride

: 1379771-10-4
N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide

: 1379771-20-6
(E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride; In N,N-dimethyl-formamide; at 85 ℃; for 0.75h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jo300458v

Reference yield:

: 1379771-08-0
2-(1-methoxybut-3-ynyl)aniline

: 1379771-20-6
(E)-2-(4-trifluoromethylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 0.75 h / 85 °C / Inert atmosphere

With pyridine; tetrabutylammomium bromide; potassium carbonate; triphenylphosphine; palladium dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo300458v