(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

Base Information

Chemical Name:(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol
CAS No.:159351-18-5
Molecular Formula:C₁₈H₃₂O₂SSi
Molecular Weight:340.602
Hs Code.:

Synonyms:(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

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Chemical Property of (R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

Chemical Property:

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Technology Process of (R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

There total 8 articles about (R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₂₉H₄₈O₃SSi₂

: 159351-18-5
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

Guidance literature:: With TBMPSBr; pyridine hydrogenfluoride; In acetonitrile;
DOI:10.1055/s-1994-25589

Reference yield:

: 104708-08-9
2-((R)-2,2-Diethyl-[1,3]dioxolan-4-yl)-2-methyl-propan-1-ol

: 159351-18-5
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / DMAP, pyridine / 16 h / Ambient temperature

2: 97 percent / t-BuOK / dimethylsulfoxide / 4 h / 80 °C

3: 50 percent / conc. H₂SO₄ / methanol / 24 h / Ambient temperature

4: 80 percent / Et₃N / dimethylformamide

5: 2,6-luthidine / CH₂Cl₂ / 0 °C

6: 100 percent / 1.) TBMPSBr, 2.) HF*pyridine / acetonitrile

With pyridine; 2,6-dimethylpyridine; dmap; TBMPSBr; sulfuric acid; potassium tert-butylate; pyridine hydrogenfluoride; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-1994-25589

Reference yield:

: 60856-63-5
(2R)-(-)-3,3-dimethylbutane-1,2,4-triol

: 159351-18-5
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: PTSA / tetrahydrofuran / 5 h / Heating

2: 100 percent / DMAP, pyridine / 16 h / Ambient temperature

3: 97 percent / t-BuOK / dimethylsulfoxide / 4 h / 80 °C

4: 50 percent / conc. H₂SO₄ / methanol / 24 h / Ambient temperature

5: 80 percent / Et₃N / dimethylformamide

6: 2,6-luthidine / CH₂Cl₂ / 0 °C

7: 100 percent / 1.) TBMPSBr, 2.) HF*pyridine / acetonitrile

With pyridine; 2,6-dimethylpyridine; dmap; TBMPSBr; sulfuric acid; potassium tert-butylate; toluene-4-sulfonic acid; pyridine hydrogenfluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1055/s-1994-25589