(S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Base Information

Chemical Name:(S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole
CAS No.:1402839-27-3
Molecular Formula:C₂₄H₃₆N₂OSi
Molecular Weight:396.648
Hs Code.:

Synonyms:(S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Suppliers and Price of (S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

There total 7 articles about (S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402839-11-5
1-((1S,3S)-3-(tert-butyldimethylsilyloxy)-3-cyclohexyl-1-(2-iodophenyl)propyl)-1H-imidazole

: 1402839-27-3
(S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Guidance literature:: 1-((1S,3S)-3-(tert-butyldimethylsilyloxy)-3-cyclohexyl-1-(2-iodophenyl)propyl)-1H-imidazole; With dicyclohexylmethylamine; triphenylphosphine; In N,N-dimethyl-formamide; for 0.25h;

palladium diacetate; In N,N-dimethyl-formamide; at 95 ℃; for 5h;

Reference yield:

: 1402839-07-9
3-cyclohexyl-3-hydroxy-1-(2-iodophenyl)propan-1-one

: 1402839-27-3
(S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 16 h / 20 °C

3.1: triethylamine / dmap / dichloromethane / 18 h / 20 °C / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 14 h / 60 °C

5.1: triphenylphosphine; dicyclohexylmethylamine / N,N-dimethyl-formamide / 0.25 h

5.2: 5 h / 95 °C

With dimethylsulfide borane complex; dicyclohexylmethylamine; sodium hydride; triethylamine; triphenylphosphine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dmap; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil; 2.1: Aldol Condensation;

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1402839-27-3
(S)-5-((S)-2-(tert-butyldimethylsilyloxy)-2-cyclohexylethyl)-5H-imidazo[5,1-α]isoindole

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.25 h / -30 °C / Inert atmosphere

1.2: 2 h / -78 - -40 °C

2.1: dmap / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 16 h / 20 °C

4.1: triethylamine / dmap / dichloromethane / 18 h / 20 °C / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 14 h / 60 °C

6.1: triphenylphosphine; dicyclohexylmethylamine / N,N-dimethyl-formamide / 0.25 h

6.2: 5 h / 95 °C

With n-butyllithium; dimethylsulfide borane complex; dicyclohexylmethylamine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dmap; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil; 3.1: Aldol Condensation;