2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Base Information

Chemical Name:2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine
CAS No.:1365530-19-3
Molecular Formula:C₂₀H₁₃Cl₂F₅N₂
Molecular Weight:447.235
Hs Code.:

Synonyms:2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Suppliers and Price of 2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

There total 3 articles about 2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 1365530-19-3
2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.2: 2 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.3: -78 - 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether; hexane / 14 h / -78 - 20 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

2.2: Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; 2.1: Grignard addition;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 946491-89-0
C₇H₅Cl₂FMg

: C₁₆H₁₅ClF₄N₂Si

: 1365530-19-3
2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Guidance literature:: C₇H₅Cl₂FMg; C₁₆H₁₅ClF₄N₂Si; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; for 14h; Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; hexane; Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 130723-13-6
3-bromo-5-fluorobenzotrifluoride

: 1365530-19-3
2-(2-chloro-4-fluorophenyl)-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.2: 2 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.3: -78 - 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether; hexane / 14 h / -78 - 20 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

2.2: Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; 2.1: Grignard addition;
DOI:10.1016/j.tet.2012.01.050