4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Base Information

Chemical Name:4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide
CAS No.:1357575-87-1
Molecular Formula:C₂₆H₃₅F₃N₄O₆S₃
Molecular Weight:652.78
Hs Code.:

Synonyms:4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

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Chemical Property of 4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

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Technology Process of 4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

There total 10 articles about 4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1357575-83-7
(S)-N-ethyl-N-(morpholin-3-ylmethyl)ethanamine hydrochloride salt

: 1357575-05-3
(R)-4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butanoic acid

: 1357575-87-1
4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 18 - 25 ℃; for 1h;

Reference yield:

: 1187929-79-8
(3S)-3-aminomethyl-4-{[(tert-butyl)oxy]carbonyl}morpholine

: 1357575-87-1
4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 0.5 h

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

3: diphenylsilane / carbonylhydridetris(triphenylphosphine)rhodium(I) / tetrahydrofuran / 0.5 h

4: hydrogenchloride; water

5: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 1 h / 18 - 25 °C

With pyridine; hydrogenchloride; diphenylsilane; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; carbonylhydridetris(triphenylphosphine)rhodium(I); In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1357575-85-9
(S)-tert-butyl 3-(acetamidomethyl)morpholine-4-carboxylate

: 1357575-87-1
4-((R)-4-((S)-3-((diethylamino)methyl)morpholino)-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

2: diphenylsilane / carbonylhydridetris(triphenylphosphine)rhodium(I) / tetrahydrofuran / 0.5 h

3: hydrogenchloride; water

4: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 1 h / 18 - 25 °C

With hydrogenchloride; diphenylsilane; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; carbonylhydridetris(triphenylphosphine)rhodium(I); In tetrahydrofuran; ISOPROPYLAMIDE; N,N-dimethyl-formamide; mineral oil;