2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Base Information

Chemical Name:2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
CAS No.:260353-65-9
Molecular Formula:C₈H₁₀FNO₄
Molecular Weight:203.17
Hs Code.:
DSSTox Substance ID:DTXSID10431169
Nikkaji Number:J1.479.166C
Wikidata:Q82244986
ChEMBL ID:CHEMBL333519
Mol file:260353-65-9.mol

Synonyms:260353-65-9;CHEMBL333519;2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid;AFBD;SCHEMBL1088473;DTXSID10431169;BDBM50094842;(+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid;(-)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid;(+/-)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid;(1R,2S,5R,6R)-2-Amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Suppliers and Price of 2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Chemical Property:

Boiling Point:363.7±42.0 °C(Predicted)
PKA:1.62±0.40(Predicted)
PSA：100.62000
Density:1.63±0.1 g/cm3(Predicted)
LogP:0.30150
XLogP3:-3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:203.05938596
Heavy Atom Count:14
Complexity:333

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C2C1C2(C(=O)O)F)(C(=O)O)N
Isomeric SMILES:C1C[C@]([C@H]2[C@@H]1[C@@]2(C(=O)O)F)(C(=O)O)N

Technology Process of 2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid

There total 11 articles about 2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 635318-09-1
(1R,2S,5R,6R)-diethyl-2-(2'R-tert-butoxycarbonylamino-propionylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 260353-63-7,260353-64-8,260353-65-9,321903-59-7
(1R,5R,6R)-2-Amino-4-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Guidance literature:: (1R,2S,5R,6R)-diethyl-2-(2'R-tert-butoxycarbonylamino-propionylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylate; With hydrogenchloride; In water; Heating / reflux;

With methyloxirane; In methanol; at 20 ℃;

Reference yield: 78.0%

: 635318-21-7
(1S,2R,5S,6S,2'R)-diethyl-2-(2'-tert-butoxycarbonylaminopropionylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylate

: 260353-63-7,260353-64-8,260353-65-9,321903-59-7
(1S,2R,5S,6S)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Guidance literature:: (1S,2R,5S,6S,2'R)-diethyl-2-(2'-tert-butoxycarbonylaminopropionylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylate; With hydrogenchloride; In water; Heating / reflux;

With methyloxirane; In methanol; at 20 ℃;