2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

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Chemical Name:2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline
CAS No.:154406-08-3
Molecular Formula:C₃₁H₂₉BrN₄O₃
Molecular Weight:585.5
Hs Code.:

Synonyms:2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

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Chemical Property of 2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

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Technology Process of 2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

There total 4 articles about 2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 16647-38-4
2-ethoxybut-2-ene

: 154406-07-2
(E)-3-(2-Azido-phenyl)-1-(8-benzyloxy-7-bromo-quinolin-2-yl)-propenone

: 154406-08-3
2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

Guidance literature:: With 2-ethoxy-but-1-ene; Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione; In dichloromethane; Heating;
DOI:10.1039/c39930001463

Reference yield:

: 16714-25-3
2-azidobenzaldehyde

: 154406-08-3
2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 10percent aq. NaOH / ethanol / 25 °C

2: 98 percent / Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione, 2-ethoxybut-1-ene / CH₂Cl₂ / Heating

With sodium hydroxide; 2-ethoxy-but-1-ene; Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione; In ethanol; dichloromethane;
DOI:10.1039/c39930001463

Reference yield:

: 99573-19-0
3-(benzyloxy)-4-bromo-2-nitrobenzaldehyde

: 154406-08-3
2-[4-(2-Azido-phenyl)-6-ethoxy-5,6-dimethyl-5,6-dihydro-4H-pyran-2-yl]-8-benzyloxy-7-bromo-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) Na₂S₂O₄, 3.) acid

2: 98 percent / 10percent aq. NaOH / ethanol / 25 °C

3: 98 percent / Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione, 2-ethoxybut-1-ene / CH₂Cl₂ / Heating

With sodium hydroxide; sodium dithionite; 2-ethoxy-but-1-ene; Yb(fod)3 Hfod=1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dione; In ethanol; dichloromethane;
DOI:10.1039/c39930001463