4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

Base Information

Chemical Name:4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide
CAS No.:1345879-60-8
Molecular Formula:C₂₅H₂₁F₂NO₅
Molecular Weight:453.442
Hs Code.:

Synonyms:4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

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Chemical Property of 4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

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Technology Process of 4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

There total 8 articles about 4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.7%

: 1221239-08-2
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one

: 1345882-00-9
4-((6-bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide

: 1345879-60-8
4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1345879-60-8
4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 87-66-1
2-hydroxyresorcinol

: 1345879-60-8
4-((3-(difluoromethoxy)-2-methoxy-6-(1-oxoindan-4-yl)-phenoxy)methyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydrogencarbonate / acetone / 16 h / Reflux

2: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

3: potassium carbonate / acetone / 7 h / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

5: hydrogenchloride; water / methanol / 1 h / 50 °C

6: potassium carbonate / acetonitrile / 16 h / 80 °C

7: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; water; potassium carbonate; potassium hydrogencarbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone; acetonitrile;