[5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

Base Information

Chemical Name:[5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester
CAS No.:1182351-07-0
Molecular Formula:C₁₇H₁₆BrClO₄
Molecular Weight:399.669
Hs Code.:

Synonyms:[5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

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Chemical Property of [5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

Chemical Property:

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Technology Process of [5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

There total 6 articles about [5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1182351-06-9
[5-(4-bromo-2-formyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

: 1182351-07-0
[5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.166667h;

Reference yield:

: 177985-33-0
2-(2-chloro-5-fluorophenyl)acetic acid

: 1182351-07-0
[5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 20 °C

1.2: 3 h / 120 °C

2.1: sulfuric acid / 20 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 50 °C / Inert atmosphere

4.1: potassium carbonate / 1,4-dioxane / 72 h / 110 °C

5.1: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

With sodium tetrahydroborate; sulfuric acid; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; mineral oil;

Reference yield:

: 1182351-05-8
(5-benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester

: 1182351-07-0
[5-(4-bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / ethanol / 50 °C / Inert atmosphere

2: potassium carbonate / 1,4-dioxane / 72 h / 110 °C

3: sodium tetrahydroborate / methanol / 0.17 h / 20 °C

With sodium tetrahydroborate; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;