Technology Process of (2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzoquinolizine

Base Information
Suppliers and Price
Chemical Property
Technology Process

Home > CAS Database list > (2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzoquinolizine

(2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzoquinolizine

Chemical Name:(2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzoquinolizine

CAS No.:73608-97-6
Molecular Formula:C₄₁H₄₆N₂O₄
Molecular Weight:630.827
Hs Code.:

(2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzo<a>quinolizine

Synonyms:(2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzoquinolizine

Suppliers and Price of (2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzo quinolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemical Property of (2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzoquinolizine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzo quinolizine

There total 24 articles about (2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzo quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 73053-55-1,73650-74-5
(+/-)-9-benzyloxy-N-(3-benzyloxy-4-methoxyphenethyl)-3α-ethyl-1,3,4,6,7,11bα-hexahydro-10-methoxy-2H-benzo quinolizine-2β-acetamide

: 73053-56-2,73608-97-6
(+/-)-9-benzyloxy-2β-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3α-ethyl-1,3,4,6,7,11bα-hexahydro-10-methoxy-2H-benzo quinolizine

Guidance literature:: With trichlorophosphate; In toluene; for 1.5h; Heating;

Reference yield: 81.0%

: 73053-55-1,73650-74-5
(2R,3R,11bS)-(-)-9-benzyloxy-N-(3-benzyloxy-4-methoxyphenetyl)-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzo quinolizine-2-acetamide

: 73608-97-6
(2R,3R,11bS)-(+)-9-benzyloxy-2-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-10-methoxy-2H-benzo quinolizine

Guidance literature:: With trichlorophosphate;
DOI:10.1248/cpb.33.583

Reference yield:

: 69700-17-0
1-(3-(benzyloxy)-4-methoxyphenyl)-2-bromoethan-1-one

: 73053-56-2,73608-97-6
(+/-)-9-benzyloxy-2β-(6-benzyloxy-3,4-dihydro-7-methoxy-1-isoquinolyl)methyl-3α-ethyl-1,3,4,6,7,11bα-hexahydro-10-methoxy-2H-benzo quinolizine

Guidance literature:: Multi-step reaction with 9 steps

1: dimethylformamide / 8 h / 60 °C

2: 99 percent / NaBH₄ / ethanol / 1.) 0-5 deg C, 30 min; 2.) room temp., 3 h

3: 93 percent / H₂ / Pd-C (10percent) / ethanol; aq. HClO₄ / 12 h / 760 Torr / Ambient temperature

4: 74 percent / K₂CO₃ / acetone / 48 h / Heating

5: 1.72 g / POCl₃ / toluene / 1.5 h / Heating

6: 1.03 g / H₂ / Adams catalyst / ethanol / 0.83 h / Ambient temperature

7: 83 percent / NaOH (2N) / ethanol / 20 h / Ambient temperature

8: 97 percent / diethyl phosphorocyanidate, Et₃N, / dimethylformamide / 6 h / Ambient temperature

9: 82 percent / POCl₃ / toluene / 1.5 h / Heating

With sodium hydroxide; sodium tetrahydroborate; diethyl cyanophosphonate; hydrogen; potassium carbonate; triethylamine; trichlorophosphate; platinum(IV) oxide; palladium on activated charcoal; In perchloric acid; ethanol; N,N-dimethyl-formamide; acetone; toluene;