1,4-Dioxaspiro[4.5]deca-6,9-dien-8-one

Base Information

• Chemical Name: 1,4-Dioxaspiro[4.5]deca-6,9-dien-8-one
• CAS No.: 35357-34-7
• Molecular Formula: C8H8 O3
• Molecular Weight: 152.15
• Hs Code.: 2932999099
• Mol file: 35357-34-7.mol

Synonyms:p-Benzoquinonemonoethylene acetal

Chemical Property of 1,4-Dioxaspiro[4.5]deca-6,9-dien-8-one

Chemical Property:

• PSA: 35.53000
• LogP: 0.42460

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-Dioxaspiro[4.5]deca-6,9-dien-8-one

There total 10 articles about 1,4-Dioxaspiro[4.5]deca-6,9-dien-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Ethylene dimethyl bisketal of benzoquinone (75714-43-1) → 1,4-dioxaspiro[4.5]deca-6,9-dien-8-one (35357-34-7)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; for 1.5h;

DOI:10.1021/jo00314a040

Reference yield: 91.0%

ethylene glycol (107-21-1) + 4-methoxy-phenol (150-76-5) → 1,4-dioxaspiro[4.5]deca-6,9-dien-8-one (35357-34-7)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.07.121

Reference yield: 91.0%

1,4-benzoquinone bis(ethylene ketal) (35357-33-6) → 1,4-dioxaspiro[4.5]deca-6,9-dien-8-one (35357-34-7)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; at 64 ℃; for 6h;

upstream raw materials:

1,4-benzoquinone bis(ethylene ketal)

Ethylene dimethyl bisketal of benzoquinone

2-(8-methoxy-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-yloxy)-ethanol

ethylene acetal of 4-(p-toluenesulphonimido)cyclohexa-2,5-dien-1-one

Refernces

• 1、 Breuning, Matthias,Corey. "Catalytic Enantioselective Diels-Alder Reactions of 1,4-Quinone Monoketals". . p. 1559 - 1562. Retrieved 2001.
• 2、 -. "Ring-fused compound, pharmaceutical composition containing same and application of compound". Paragraph 0287-0289. . Retrieved 2018/04/01.
• 3、 Craven, Philip G.E.,Taylor, Richard J.K.. "Total synthesis and structural confirmation of (±)-cuevaene A". supporting information. p. 5422 - 5425. Retrieved 2012/10/30.