((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Base Information

Chemical Name:((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate
CAS No.:322468-23-5
Molecular Formula:C₂₉H₃₈BrO₆PSi
Molecular Weight:621.58
Hs Code.:

Synonyms:((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Suppliers and Price of ((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of ((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

There total 8 articles about ((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phosphorous acid 2-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-propyl ester 2-bromo-ethyl ester methyl ester

: 322468-23-5
((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Guidance literature:: With dihydrogen peroxide; In dichloromethane; for 2h;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 17618-04-1
2,5-di-O-benzyl-D-mannitol

: 322468-23-5
((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / DMAP; Et₃N / CH₂Cl₂ / 6 h / 20 °C

2: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

3: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

4: imidazole / dimethylformamide / 20 °C

5: pyridinium chloride; EtOH / 2 h / Heating

6: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

7: tetrahydrofuran / 2 h / -78 - 20 °C

8: 30 percent aq.H₂O₂ / CH₂Cl₂ / 2 h

With 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(00)00167-5

Reference yield:

: 90126-86-6
2,5-di-O-benzyl-1,6-di-O-trityl-D-mannitol

: 322468-23-5
((S)-2-O-benzyl-3-O-tertbutyldiphenylsilylglyceryl)-2-bromoethyl-methylphosphate

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / aq. NaIO₄ / tetrahydrofuran / 2 h

2: 92 percent / NaBH₄ / methanol / 4 h / 20 °C

3: imidazole / dimethylformamide / 20 °C

4: pyridinium chloride; EtOH / 2 h / Heating

5: i-Pr₂NEt / tetrahydrofuran / 1 h / -78 °C

6: tetrahydrofuran / 2 h / -78 - 20 °C

7: 30 percent aq.H₂O₂ / CH₂Cl₂ / 2 h

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; ethanol; dihydrogen peroxide; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0009-3084(00)00167-5