1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

Base Information

Chemical Name:1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane
CAS No.:198904-59-5
Molecular Formula:C₂₅H₃₂N₄O₃S
Molecular Weight:468.62
Hs Code.:

Synonyms:1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

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Chemical Property of 1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

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Technology Process of 1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

There total 5 articles about 1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 198904-58-4
N'-[(2S,3S)-2-Hydroxy-4-phenyl-3-(2,2,2-trifluoro-acetylamino)-butyl]-N'-(4-thiazol-2-yl-benzyl)-hydrazinecarboxylic acid tert-butyl ester

: 198904-59-5
1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

Guidance literature:: With potassium carbonate; In methanol; for 3h; Heating;
DOI:10.1021/jm970873c

Reference yield:

: 24856-58-4
1,1-dimethoxy-1-(4-bromophenyl)methane

: 198904-59-5
1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg, I₂, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl

2: 73 percent / ethanol / 4 h / Heating

3: 1.) NaCNBH₃, p-TsOH, 2.) aq. NaOH / 1.) THF, RT, 37 h, 2.) THF, reflux, 3.5 h

4: 73 percent / propan-2-ol / 16 h / 80 °C

5: 91 percent / aq. K₂CO₃ / methanol / 3 h / Heating

With hydrogenchloride; sodium hydroxide; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); iodine; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; magnesium; In methanol; ethanol; isopropyl alcohol;
DOI:10.1021/jm970873c

Reference yield:

: 198904-53-9
4-(thiazol-2-yl)-benzaldehyde

: 198904-59-5
1-[4-(thiazol-2-yl)-phenyl]-4(S)-hydroxy-2-(tert-butoxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / ethanol / 4 h / Heating

2: 1.) NaCNBH₃, p-TsOH, 2.) aq. NaOH / 1.) THF, RT, 37 h, 2.) THF, reflux, 3.5 h

3: 73 percent / propan-2-ol / 16 h / 80 °C

4: 91 percent / aq. K₂CO₃ / methanol / 3 h / Heating

With sodium hydroxide; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; In methanol; ethanol; isopropyl alcohol;
DOI:10.1021/jm970873c