4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

Base Information

Chemical Name:4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane
CAS No.:858642-02-1
Molecular Formula:C₆₇H₁₁₀N₁₀O₁₆
Molecular Weight:1311.67
Hs Code.:

Synonyms:4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

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Chemical Property of 4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

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Technology Process of 4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

There total 6 articles about 4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 603956-15-6
4,4'-bis(2-aminoethoxy)diphenylmethane

: 247193-74-4
2-(4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid

: 858642-02-1
4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1248/cpb.53.444

Reference yield:

: 603956-14-5
4,4'-bis(pentafluorophenoxycarbonylmethoxy)diphenylmethane

: 858642-02-1
4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / aq. NH₃ / tetrahydrofuran / 12 h / 20 °C

2: 85 percent / BH₃*Me₂S / tetrahydrofuran / 24 h / 80 °C

3: 56 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / CH₂Cl₂ / 24 h / 20 °C

With ammonium hydroxide; dimethylsulfide borane complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.53.444

Reference yield:

: 620-92-8
bis-(4-hydroxyphenyl)methane

: 858642-02-1
4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 24 h / 20 °C

2: 100 percent / KOH / methanol / 2 h / Heating

3: 92 percent / N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 24 h / 20 °C

4: 98 percent / aq. NH₃ / tetrahydrofuran / 12 h / 20 °C

5: 85 percent / BH₃*Me₂S / tetrahydrofuran / 24 h / 80 °C

6: 56 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / CH₂Cl₂ / 24 h / 20 °C

With potassium hydroxide; ammonium hydroxide; dimethylsulfide borane complex; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.444