247193-74-4

Basic information

• Product Name: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID
• Synonyms: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID;1,4,7-tris-Boc-(10-carboxymethyl)-1,4,7,10-tetraaza-cyclododecan;(4,7,10-tris-Boc-1,4,7,10-tetraaza-cyclododecan-1-yl)-acetic acid;1,4,7-Tri-Boc-10-(carboxyMethyl)-1,4,7,10-tetraazacyclododecane;1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane 98% (TLC);1,4,7,10-Tetraazacyclododecane-1,4,7-tricarboxylic acid, 10-(carboxymethyl)-, 1,4,7-tris(1,1-dimethylethyl) ester;10-carboxymethyl-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester;1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane, 97.5%
• CAS NO: 247193-74-4
• Molecular Formula: C₂₅H₄₆N₄O₈
• Molecular Weight: 530.65
• Mol File: 247193-74-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 611.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.126±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID(247193-74-4)
• EPA Substance Registry System: (4,7,10-TRI-BOC-1,4,7,10-TETRAAZACYCLODECAN-1-YL)ACETIC ACID(247193-74-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• Hazardous Substances Data: 247193-74-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Different sources of media describe the Uses of 247193-74-4 differently. You can refer to the following data:
1. 1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (CAS# 247193-74-4) is a bifunctional chelating agent, whose Zn(II) complexes are able to undergo RNA-binding and behave as potential antimicrobial agents.
2. Building block used to attach the Cyclen azacrown to a molecular scaffold; selective cleavage of the HIV-1 TAR-RNA with a peptide-cyclen conjugate

Upstream product

• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 24424-99-5 di-tert-butyl dicarbonate 
• 175854-39-4 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 

Downstream Products

• 858642-02-1 4,4'bis{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecane-1-yl]acetylaminoethoxy}diphenylmethane 
• 862097-47-0 10-{[(3-benzyloxycarbonylaminopropyl)ethoxycarbonylmethylcarbamoyl]methyl}-1,4,7,10-tetraazacyclododecane-1,4,7,-tricarboxylic acid tri-tert-butyl ester 
• 1609955-65-8 C₅₁H₈₈ClN₇O₁₀ 
• 1609955-66-9 C₅₅H₉₆ClN₇O₁₀ 
• 1609955-67-0 C₅₇H₁₀₀ClN₇O₁₀ 
• 1612753-17-9 tri-tert-butyl 10-(2-((4-methoxy-3,5-bis(methylcarbamoyl)benzyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylate 
• 640731-06-2 methyl N²-[(benzyloxy)carbonyl]-N⁶-{[4,7,10-tris-(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetyl}-L-lysinate 
• 1173758-78-5 4,4'-bis[2-(N-{2-[4,7,10-tris(tert-butoxycarbonyl)-1,4,7,10-tetraazacyclodecan-1-yl]acetyl}-N-phenethyl)aminoethoxy]diphenylmethane 

Relevant articles and documents

Selective cleavage of the HIV-1 TAR-RNA with a peptide-cyclen conjugate

Covalent linkage of the arginine-rich fragment of the Tat protein to 1,4,7,10-tetraazacyclododecane (cyclen) results in the selective cleavage of the TAR-RNA of HIV-1 (see picture; the biotin at the 5' end acts as a label for the subsequent analysis of the cleavage fragments). The cleavage occurs at room temperature and is diminished when Eu(III) ions are present - at a concentration of about 1/10 of the concentration of the peptide-cyclen conjugate. The pH dependence indicates that two ammonium ions are responsible for the cleavage reaction. The white arrows in the schematic diagram mark the cleavage sites in RNaseT1, and the black arrows the sites in the peptide- cyclen conjugate.

ANTIBACTERIAL COMPOUNDS

The invention relates to antibacterial compounds, methods for synthesis and use thereof in antibacterial applications.

Synthetic catalyst for selective cleavage of protein and method for selective cleavage of protein using the same

The present invention relates to a synthetic catalyst of the following formula (A) which can selectively recognize and cleave a specific protein among a protein mixture, and to a method for selective cleavage of a target protein using the same: (R)(Z)sub