3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester

Base Information

• Chemical Name: 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester
• CAS No.: 1198093-71-8
• Molecular Formula: C₁₅H₂₃N₃O₄
• Molecular Weight: 309.365
• Mol file: 1198093-71-8.mol

Synonyms:3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester

Chemical Property of 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester

There total 4 articles about 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2-tert-butoxycarbonylamino-ethylamino)-3-nitro-benzoic acid methyl ester (1198093-70-7) → 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester (1198093-71-8)

Guidance literature:

With 1% Pd/C; hydrogen; In methanol; at 20 ℃; for 17h; under 760.051 Torr;

DOI:10.1002/chem.200901376

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester (1198093-71-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 6 h / 65 °C

2: triethylamine / dichloromethane / 25 h / 20 °C

3: palladium on carbon; hydrogen / methanol / 17 h / 20 °C

With sulfuric acid; palladium on carbon; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.2533/chimia.2010.136

Reference yield:

4-fluoro-3-nitro-benzoic acid methyl ester (329-59-9) → 3-amino-4-(2-tert-butoxycarbonylamino-ethylamino)-benzoic acid methyl ester (1198093-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 25 h / 20 °C

2: palladium on carbon; hydrogen / methanol / 17 h / 20 °C

With palladium on carbon; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.2533/chimia.2010.136

upstream raw materials:

4-(2-tert-butoxycarbonylamino-ethylamino)-3-nitro-benzoic acid methyl ester

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitro-benzoic acid methyl ester

Downstream raw materials:

C₁₇H₂₃N₃O₄

C₁₆H₂₃N₃O₃

C₁₆H₂₁N₃O₃

C₁₉H₂₇N₃O₃