1198093-70-7Relevant academic research and scientific papers
Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof
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Page/Page column 141, (2011/09/14)
Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting
Dietrich, Silvia Anthoine,Riediker, Linda,Gertsch, Juerg,Altmann, Karl-Heinz
scheme or table, p. 136 - 139 (2011/07/31)
Epothilones are potent antiproliferative agents, which have served as successful lead structures for anticancer drug discovery. However, their therapeutic efficacy would benefit greatly from an increase in their selectivity for tumor cells, which may be a
Epothilone analogues with benzimidazole and quinoline side chains: Chemical synthesis, antiproliferative activity, and interactions with tubulin
Dietrich, Silvia Anthoine,Lindauer, Renate,Stierlin, Claire,Gertsch, Juerg,Matesanz, Ruth,Notararigo, Sara,Diaz, Jose Fernando,Altmann, Karl-Heinz
experimental part, p. 10144 - 10157 (2010/04/30)
A series of epothilone B and D analogues bearing isomeric quinoline or functionalized benzimidazole side chains has been prepared by chemical synthesis in a highly convergent manner. All analogues have been found to interact with the tubulin/microtubule s
