N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide

Base Information

• Chemical Name: N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide
• CAS No.: 1333427-33-0
• Molecular Formula: C₁₆H₂₁NOS
• Molecular Weight: 275.415

Synonyms:N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide

Chemical Property of N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide

There total 2 articles about N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(S)-1-methyl-1-(trans-4-methylcyclohexyl)prop-2-ynylamine hydrochloride + 3-Thiophene carboxylic acid (88-13-1) → N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide (1333427-33-0)

Guidance literature:

3-Thiophene carboxylic acid; With 2,3,4,5,6-pentafluorophenol; In dichloromethane; for 0.5h;

In dichloromethane; at 20 ℃; for 18h;

(S)-1-methyl-1-(trans-4-methylcyclohexyl)prop-2-ynylamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 60 ℃; for 30h;

DOI:10.1021/jacs.5b00315

Reference yield:

3-thiophene carboxylic acid chloride (41507-35-1) + C11H19N*(x)ClH → N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide (1333427-33-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 16h;

Reference yield: 91.0%

N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide (1333427-33-0) + (S)-2-azido-6-((tert-butoxycarbonyl)amino)hexanoic acid (333366-32-8) → (S)-6-((tert-butoxycarbonyl)amino)-2-(4-((S)-1-((1R,4S)-4-methylcyclohexyl)-1-(thiophene-3-carboxamido)ethyl)-1H-1,2,3-triazol-1-yl)hexanoic acid

Guidance literature:

With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 24h;

DOI:10.1021/jacs.5b00315

upstream raw materials:

3-thiophene carboxylic acid chloride

3-Thiophene carboxylic acid

Downstream raw materials:

C₃₁H₄₄N₄O₃S₂

C₁₆H₂₂N₄OS

thiophene-3-carboxylic acid [(S)-1-(2-cyanomethyl-2H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1333427-33-0 N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send