thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

Base Information

Chemical Name:thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide
CAS No.:1333426-09-7
Molecular Formula:C₁₈H₂₃N₅OS
Molecular Weight:357.48
Hs Code.:

Synonyms:thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

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Chemical Property of thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

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Technology Process of thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

There total 8 articles about thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333428-59-3
C₁₆H₂₂N₄OS

: 590-17-0
cyanomethyl bromide

: 1333426-10-0
thiophene-3-carboxylic acid [(S)-1-(2-cyanomethyl-2H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

: 1333426-09-7
thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

Guidance literature:: C₁₆H₂₂N₄OS; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

cyanomethyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 41507-35-1
3-thiophene carboxylic acid chloride

: 1333426-10-0
thiophene-3-carboxylic acid [(S)-1-(2-cyanomethyl-2H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

: 1333426-09-7
thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 16 h

2.1: copper(I) thiophene-2-carboxylate / toluene / 48 h

3.1: trimethylsilyl cyanide / chloroform / 0.33 h / 140 °C / Microwave irradiation

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 2 h / 20 °C

With trimethylsilyl cyanide; sodium hydride; triethylamine; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1333427-33-0
N-((S)-2-((1R,4S)-4-methylcyclohexyl)but-3-yn-2-yl)thiophene-3-carboxamide

: 1333426-10-0
thiophene-3-carboxylic acid [(S)-1-(2-cyanomethyl-2H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

: 1333426-09-7
thiophene-3-carboxylic acid [(S)-1-(1-cyanomethyl-1H-[1,2,3]triazol-4-yl)-1-(4-methyl-cyclohexyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(I) thiophene-2-carboxylate / toluene / 48 h

2.1: trimethylsilyl cyanide / chloroform / 0.33 h / 140 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 2 h / 20 °C

With trimethylsilyl cyanide; sodium hydride; copper(I) thiophene-2-carboxylate; In chloroform; N,N-dimethyl-formamide; toluene; mineral oil;