ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

Base Information

Chemical Name:ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate
CAS No.:111783-49-4
Molecular Formula:C₂₃H₂₁F₄NO₅
Molecular Weight:467.417
Hs Code.:

Synonyms:ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

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Chemical Property of ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

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Technology Process of ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

There total 4 articles about ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 100828-09-9
ethyl 3-(2-hydroxyanilino)-2-(2,3,4,5-tetrafluoro)benzoylacrylate

: 111783-49-4
ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

Guidance literature:: With hydrogenchloride; In dichloromethane; Ambient temperature; overnight;
DOI:10.1002/jhet.5570240228

Reference yield:

: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

: 111783-49-4
ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂, DMF / 4 h / 80 °C

2: 1.) biquinoline, n-butyllithium / 1.) THF, hexane, -30 to -5 deg C; 2.) THF, -50 deg C, 0.5 h

3: acetic anhydride / 1) 130 deg C, 4 h; 2) 2 h

4: 71 percent / 12N aq.HCl / CH₂Cl₂ / Ambient temperature; overnight

With hydrogenchloride; n-butyllithium; thionyl chloride; biquinoline; acetic anhydride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1002/jhet.5570240228

Reference yield:

: 94695-50-8
ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate

: 111783-49-4
ethyl 3-(2-tetrahydropyranoxyanilino)-2-(2,3,4,5-tetrahydrofluoro)benzoylacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 1) 130 deg C, 4 h; 2) 2 h

2: 71 percent / 12N aq.HCl / CH₂Cl₂ / Ambient temperature; overnight

With hydrogenchloride; acetic anhydride; In dichloromethane;
DOI:10.1002/jhet.5570240228