4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

Base Information

Chemical Name:4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine
CAS No.:1620955-85-2
Molecular Formula:C₁₇H₂₆BNO₅S
Molecular Weight:367.274
Hs Code.:

Synonyms:4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

Suppliers and Price of 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

There total 2 articles about 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 950255-96-6
4-((4-bromobenzyl)sulfonyl)morpholine

: 73183-34-3
bis(pinacol)diborane

: 1620955-85-2
4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 65 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01292

Reference yield:

: 53531-69-4
(4-bromo-phenyl)-methanesulfonyl chloride

: 1620955-85-2
4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 16 h / 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane;

Reference yield: 80.0%

: 1620955-85-2
4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine

: 1,2,4-trichloro-5-(2-fluoro-3-iodobenzyl)benzene

: 4-(((2'-fluoro-3'-(2,4,5-trichlorobenzyl)-[1,1'-biphenyl]-4-yl)methyl)sulfonyl)morpholine

Guidance literature:: 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)sulfonyl)morpholine; 1,2,4-trichloro-5-(2-fluoro-3-iodobenzyl)benzene; With potassium carbonate; In ethanol; water; toluene; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01292