N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

Base Information

Chemical Name:N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide
CAS No.:1282541-12-1
Molecular Formula:C₁₅H₁₃F₃N₂O₃
Molecular Weight:326.275
Hs Code.:

Synonyms:N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

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Chemical Property of N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

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Technology Process of N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

There total 5 articles about N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 454-81-9
2-amino-4-(trifluoromethyl)phenol

: 1192021-83-2
3-methoxymethyl isonicotinic acid

: 1282541-12-1
N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 100-55-0
3-hydroxymethylpyridin

: 1282541-12-1
N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: dihydrogen peroxide; acetic acid / 4 h / 80 °C

3.1: ethyl iodide / 1 h / 60 °C

3.2: 1 h / 50 °C

4.1: sodium hydroxide; water / ethanol / 3 h / Reflux

4.2: pH ~ 3

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With water; dihydrogen peroxide; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ethyl iodide; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 58418-62-5
3-(methoxymethyl)pyridine

: 1282541-12-1
N-[2-hydroxy-5-(trifluoromethyl)phenyl]-3-(methoxymethyl)isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; acetic acid / 4 h / 80 °C

2.1: ethyl iodide / 1 h / 60 °C

2.2: 1 h / 50 °C

3.1: sodium hydroxide; water / ethanol / 3 h / Reflux

3.2: pH ~ 3

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

With water; dihydrogen peroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ethyl iodide; acetic acid; triethylamine; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;