tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

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Chemical Name:tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate
CAS No.:1354819-30-9
Molecular Formula:C₂₈H₂₆ClF₂N₅O₈S₂
Molecular Weight:698.125
Hs Code.:

tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Synonyms:tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

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Chemical Property of tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

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Technology Process of tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

There total 3 articles about tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1354819-30-9
tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / toluene / 23 h / 80 °C

1.2: 4 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

With potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; toluene;

Reference yield:

: 259209-20-6
5-fluoro-2-hydroxyphenyl-boronic acid

: 1354819-30-9
tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / toluene / 23 h / 80 °C

1.2: 4 h / 80 °C / Inert atmosphere

2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

With potassium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; toluene;

Reference yield:

: 1235406-42-4
thiazol-4-ylaminocarboxylic acid tert-butyl ester

: 1354819-30-9
tert-butyl [(5-chloro-2-fluoro-4-{4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenoxy}phenyl)sulfonyl]1,3-thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

1.2: -78 - 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide;