cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone

Base Information

• Chemical Name: cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone
• CAS No.: 1276045-07-8
• Molecular Formula: C₁₈H₂₅NO₂
• Molecular Weight: 287.402
• Mol file: 1276045-07-8.mol

Synonyms:cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone

Chemical Property of cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone

There total 5 articles about cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclopentanecarboxylic acid chloride (4524-93-0) + 4-(3-methoxy-phenyl)-piperidine trifluoroacetate (1307314-95-9) → cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone (1276045-07-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2010.12.068

Reference yield:

4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (1276045-26-1) → cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone (1276045-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmcl.2010.12.068

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) → cyclopentyl(4-(3-methoxyphenyl)piperidin-1-yl)methanone (1276045-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 20 °C / 10343.2 Torr

3: dichloromethane / 1 h / 20 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2010.12.068

upstream raw materials:

4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Cyclopentanecarboxylic acid chloride

4-(3-methoxy-phenyl)-piperidine trifluoroacetate

3-methoxy-1-iodobenzene