(R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol

Base Information

• Chemical Name: (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol
• CAS No.: 97480-25-6
• Molecular Formula: C₃₁H₄₂O₄Si
• Molecular Weight: 506.758
• Mol file: 97480-25-6.mol

Synonyms:(R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol

Chemical Property of (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol

There total 5 articles about (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxy]-pentane-1,4-diol (97480-24-5) → (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol (97480-25-6)

Guidance literature:

With 1H-imidazole;

DOI:10.1021/jo990877k

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol (97480-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent

2: LiBH₄ / tetrahydrofuran

3: 80 percent / imidazole

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; 1: Substitution / 2: Reduction / 3: Substitution;

DOI:10.1021/jo990877k

Reference yield:

(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone (52813-63-5) → (R)-5-(tert-butyldimethylsiloxy)-1-(monomethoxytrityloxymethyl)-2-pentanol (97480-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent

2: LiBH₄ / tetrahydrofuran

3: 80 percent / imidazole

With 1H-imidazole; lithium borohydride; In tetrahydrofuran; 1: Substitution / 2: Reduction / 3: Substitution;

DOI:10.1021/jo990877k

upstream raw materials:

tert-butyldimethylsilyl chloride

(R)-5-[(4-Methoxy-phenyl)-diphenyl-methoxy]-pentane-1,4-diol

(5R)-2,3,4,5-tetrahydro-5-hydroxymethyl-2-furanone

mono-4-methoxytrityl chloride

Downstream raw materials:

(2S,3R)-3-Benzyloxy-2-(3-hydroxy-2-oxo-propyl)-piperidine-1-carboxylic acid tert-butyl ester

3-benzyloxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester

3-benzyloxy-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester

(4R,5R)-5-(benzyloxy)-8-(tert-butyldimethylsiloxy)-4-((2'-methoxyphenyl)amino)-2-octanone