Technology Process of Boc-Gly-Val-Sar-Sar-OCH2C6H5
There total 6 articles about Boc-Gly-Val-Sar-Sar-OCH2C6H5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
a) -15 deg C up to r.t., b) r.t., 4 h;
DOI:10.1002/hlca.19930760138
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 2.) DMF, a) -15 deg C, 30 min, b) r.t., 30 min.
2: 98 percent / H2 / 10percent Pd/C / methanol
3: 72 percent / Et(i-Pr)2N, BOP-Cl / CH2Cl2 / a) -15 deg C up to r.t., b) r.t., 4 h
4: 99 percent / H2 / 10percent Pd/C / methanol
5: 79 percent / Et(i-Pr)2N, BOP-Cl / CH2Cl2 / a) -15 deg C up to r.t., b) r.t., 4 h
With
4-methyl-morpholine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/hlca.19930760138
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) N-methylmorpholine, isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, -15 deg C, 2.) DMF, a) -15 deg C, 30 min, b) r.t., 30 min.
2: 98 percent / H2 / 10percent Pd/C / methanol
3: 72 percent / Et(i-Pr)2N, BOP-Cl / CH2Cl2 / a) -15 deg C up to r.t., b) r.t., 4 h
4: 99 percent / H2 / 10percent Pd/C / methanol
5: 79 percent / Et(i-Pr)2N, BOP-Cl / CH2Cl2 / a) -15 deg C up to r.t., b) r.t., 4 h
With
4-methyl-morpholine; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/hlca.19930760138
